New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities

Atta-ur-Rahman; Muhammad Nadeem Akhtar; Muhammad Iqbal Choudhary; Yoshisuke Tsuda; Bilge Sener; Assad Khalid; Masood Parvez

doi:10.1248/cpb.50.1013

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New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities

Atta-ur-Rahman, Muhammad Nadeem Akhtar, Muhammad Iqbal Choudhary, Yoshisuke Tsuda, Bilge Sener, Assad Khalid, Masood Parvez

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Keywords: Fritillaria imperialis, impericine, forticine, cevanine-type, acetylcholinesterase, butyrylcholinesterase

JOURNAL FREE ACCESS

2002 Volume 50 Issue 8 Pages 1013-1016

DOI https://doi.org/10.1248/cpb.50.1013

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Abstract

Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5α-cevanin-23-ene-3β,6β,16β-triol] and forticine (2) [(20S,22S,25S)-5α-cevanine-3β,6β-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.

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