Effective Isolation of Magnesium Lithospermate B and Its Inhibition of Aldose Reductase and Fibronectin on Mesangial Cell Line

Mankil Jung; Hyun Chul Lee; Chul Woo Ahn; Whuijung Park; Sunhee Choi; Hanjo Kim; Donghak Cho; Geun Taek Lee; Hai-Ri Li

doi:10.1248/cpb.50.1135

Notes

Effective Isolation of Magnesium Lithospermate B and Its Inhibition of Aldose Reductase and Fibronectin on Mesangial Cell Line

Mankil Jung, Hyun Chul Lee, Chul Woo Ahn, Whuijung Park, Sunhee Choi, Hanjo Kim, Donghak Cho, Geun Taek Lee, Hai-Ri Li

Author information

Mankil Jung
Department of Chemisty, Yonsei University
Hyun Chul Lee
Division of Endocrinology and Department of Internal Medicine, College of Medicine, Yonsei University
Chul Woo Ahn
Division of Endocrinology and Department of Internal Medicine, College of Medicine, Yonsei University
Whuijung Park
Department of Chemisty, Yonsei University
Sunhee Choi
Department of Chemisty, Yonsei University
Hanjo Kim
Department of Chemisty, Yonsei University
Donghak Cho
Department of Chemisty, Yonsei University
Geun Taek Lee
Department of Biochemistry, Yonsei University
Hai-Ri Li
Division of Endocrinology and Department of Internal Medicine, College of Medicine, Yonsei University

Keywords: magnesium lithospermate B, aldose reductase, fibronectin, Salviae miltiorrhizae Radix, antidiabetics

JOURNAL FREE ACCESS

2002 Volume 50 Issue 8 Pages 1135-1136

DOI https://doi.org/10.1248/cpb.50.1135

Details

Abstract

We developed an effective isolation method of magnesium lithospermate B from Salviae miltiorrhizae Radix and found for the first time that magnesium lithospermate B shows strong in vitro inhibition (IC₅₀=0.04 μM) of aldose reductase (AR), 2.5 times than that of clinically used epalrestat (IC₅₀=0.1 μM) and accumulation of fibronectin dose dependantly.

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