Transformation of Cinchona Alkaloids into 1-N-Oxide Derivatives by Endophytic Xylaria sp. Isolated from Cinchona pubescens

Hirotaka Shibuya; Chinami Kitamura; Shoji Maehara; Marie Nagahata; Hendig Winarno; Partomuan Simanjuntak; Hye-Sook Kim; Yusuke Wataya; Kazuyoshi Ohashi

doi:10.1248/cpb.51.71

Regular Articles

Transformation of Cinchona Alkaloids into 1-N-Oxide Derivatives by Endophytic Xylaria sp. Isolated from Cinchona pubescens

Hirotaka Shibuya, Chinami Kitamura, Shoji Maehara, Marie Nagahata, Hendig Winarno, Partomuan Simanjuntak, Hye-Sook Kim, Yusuke Wataya, Kazuyoshi Ohashi

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Keywords: Cinchona pubescens, endophyte, Xylaria sp., microbial transformation, Cinchona alkaloid, antimalarial activity

JOURNAL FREE ACCESS

2003 Volume 51 Issue 1 Pages 71-74

DOI https://doi.org/10.1248/cpb.51.71

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Abstract

The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

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