Controlled Release of Vitamin E from Thermo-Responsive Polymeric Physico-Gel

Masato Ishida; Hideki Sakai; Shinji Sugihara; Sadahito Aoshima; Shoko Yokoyama; Masahiko Abe

doi:10.1248/cpb.51.1348

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Controlled Release of Vitamin E from Thermo-Responsive Polymeric Physico-Gel

Masato Ishida, Hideki Sakai, Shinji Sugihara, Sadahito Aoshima, Shoko Yokoyama, Masahiko Abe

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Keywords: thermo-sensitive copolymer, drug delivery system, vitamin E, sol–gel transition, polymeric micelle

JOURNAL FREE ACCESS

2003 Volume 51 Issue 11 Pages 1348-1349

DOI https://doi.org/10.1248/cpb.51.1348

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Abstract

Thermo-sensitive copolymer consists of poly(2-ethoxyethyl vinyl ether) and poly(hydroxyethyl vinyl ether) (EOVE200–HOVE400), whose sol–gel transition temperature was 20.5 °C, was synthesized and its applicability to a drug delivery system was examined. Vitamin E (VE) was enclosed in EOVE200–HOVE400 and the release of VE was measured by varying the temperature 10⇔30 °C. There was no release of VE from EOVE200–HOVE400 at 30 °C, while VE was released when the temperature was reduced to 10 °C.

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