Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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O-Demethylation and Sulfation of 7-Methoxylated Flavanones by Cunninghamella elegans
Abdel-Rahim Sayed IbrahimAhmed Mohamed GalalMohammed Shamim AhmedGabir Salem Mossa
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2003 Volume 51 Issue 2 Pages 203-206

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Abstract

Metabolism of 7-O-methylnaringenin (sakuranetin) by Cunninghamella elegans NRRL 1392 yielded naringenin and naringenin-4′-sulfate. C. elegans also converted 5, 3′, 4′-trihydroxy-7-methoxyflavanone into eriodictyol-4′-sulfate. Furthermore, incubation of 5, 4′-dihydroxy-7, 3′-dimethoxyflavanone with the same fungus gave homoeriodictyol (5, 7, 4′-trihydroxy-3′-methoxyflavanone) and homoeriodicytol-7-sulfate. The structures of the new metabolites were established by spectral analysis including 2D-NMR, HR-ESI-FT-MS beside hydrolysis by acid.

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© 2003 The Pharmaceutical Society of Japan
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