Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Two Novel Sesquiterpene Lactones, Cytotoxic Vernolide-A and -B, from Vernonia cinerea
Yao-Haur KuoYu-Jen KuoAng-Su YuMing-Der WuChi-Wi OngLi-Ming Yang KuoJo-Ti HuangChieh-Fu ChenShyh-Yuan Li
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2003 Volume 51 Issue 4 Pages 425-426

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Abstract

Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B. Their structures were elucidated on the basis of spectroscopic analysis. Biological evaluation showed that vernolide-A demonstrated potent cytotoxicity against human KB, DLD-1, NCI-661, and Hela tumor cell lines (ED50=0.02, 0.05, 0.53, 0.04 μg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED50=3.78, 5.88, 6.42 μg/ml for KB, NCI-661, and Hela, respectively).

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© 2003 The Pharmaceutical Society of Japan
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