Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum

Xing Fu Cai; Guanghai Shen; Nguyen Tien Dat; Ok Hwa Kang; Jin A Kim; Young Mi Lee; Jung Joon Lee; Young Ho Kim

doi:10.1248/cpb.51.605

Notes

Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum

Xing Fu Cai, Guanghai Shen, Nguyen Tien Dat, Ok Hwa Kang, Jin A Kim, Young Mi Lee, Jung Joon Lee, Young Ho Kim

Author information

Keywords: Acanthopanax koreanum, IL-8, TNF-α, inhibitory effect, diterpenoid

JOURNAL FREE ACCESS

2003 Volume 51 Issue 5 Pages 605-607

DOI https://doi.org/10.1248/cpb.51.605

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Abstract

A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH₂Cl₂ fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-α-stimulated human colon adenocarcinoma cell line HT-29 and on the TNF-α secretion of the trypsin-stimulated human leukemic mast cell line HMC-1.

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