1,3-Dimethylisoguaninium, an Antiangiogenic Purine Analog from the Sponge Amphimedon paraviridis

Sei-Joon Jeong; Masanori Inagaki; Ryuichi Higuchi; Tomofumi Miyamoto; Mayumi Ono; Michihiko Kuwano; Rob W. M. Van Soest

doi:10.1248/cpb.51.731

Notes

1,3-Dimethylisoguaninium, an Antiangiogenic Purine Analog from the Sponge Amphimedon paraviridis

Sei-Joon Jeong, Masanori Inagaki, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Rob W. M. Van Soest

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Keywords: antiangiogenesis, purine analog, 1,3-dimethylisoguaninium, marine sponge, Amphimedon paraviridis

JOURNAL FREE ACCESS

2003 Volume 51 Issue 6 Pages 731-733

DOI https://doi.org/10.1248/cpb.51.731

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Abstract

An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

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