Ent-kaurane Diterpenoids from Isodon rubescens var. lushanensis

Quan-Bin Han; Ma-Lin Li; Sheng-Hong Li; Yi-Kun Mou; Zhong-Wen Lin; Han-Dong Sun

doi:10.1248/cpb.51.790

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Ent-kaurane Diterpenoids from Isodon rubescens var. lushanensis

Quan-Bin Han, Ma-Lin Li, Sheng-Hong Li, Yi-Kun Mou, Zhong-Wen Lin, Han-Dong Sun

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Keywords: Isodon rubescens var. lushanensis, Labiatae, ent-kauranoid, lushanrubescensin F, lushanrubescensin I, cytotoxity

JOURNAL FREE ACCESS

2003 Volume 51 Issue 7 Pages 790-793

DOI https://doi.org/10.1248/cpb.51.790

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Abstract

Four new ent-kaurane diterpenoids lushanrubescensins F—I (1—4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5—10 were evaluated.

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