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Chemical and Pharmaceutical Bulletin
Vol. 51 (2003) No. 7 P 857-859

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http://doi.org/10.1248/cpb.51.857

Notes

Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. α- and β-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 μg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.

Copyright © 2003 The Pharmaceutical Society of Japan

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