Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana

Abstract

Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. α- and β-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 μg/ml. Tri- and tetra-oxygenated xanthones with di-C₅ units or with a C₅ and a modified C₅ groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.