Carbocyclic Analogues of Nucleosides from bis-(Hydroxymethyl)-cyclopentane: Synthesis, Antiviral and Cytostatic Activities of Adenosine, Inosine and Uridine Analogues

Abstract

Six new carbocyclic nucleosides were prepared by constructing a purine base (in compounds 9—11) or pyrimidine base (in 6—8) on the amino groups of (±)-(1β,2α,4β)-4-amino-1,2-cyclopentanedimethanol (4) and (±)-(1β,3α,4β)-4-amino-1,3-cyclopentanedimethanol (5), and their activities against a variety of viruses and tumour cell lines were determined.