Cyclooxygenase Inhibitors Derived from Thalidomide

Mamiko Suizu; Yohei Muroya; Hiroki Kakuta; Hiroyuki Kagechika; Aya Tanatani; Kazuo Nagasawa; Yuichi Hashimoto

doi:10.1248/cpb.51.1098

Notes

Cyclooxygenase Inhibitors Derived from Thalidomide

Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

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Keywords: thalidomide, cyclooxygenase, inhibitor, structure–activity relationship

JOURNAL FREE ACCESS

2003 Volume 51 Issue 9 Pages 1098-1102

DOI https://doi.org/10.1248/cpb.51.1098

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Abstract

Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

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