Cytotoxic C-Benzylated Dihydrochalcones from Uvaria acuminata

Momoyo Ichimaru; Noriyoshi Nakatani; Tomoko Takahashi; Yumi Nishiyama; Masataka Moriyasu; Atsushi Kato; Simon G. Mathenge; Francis D. Juma; Joseph N. Nganga

doi:10.1248/cpb.52.138

Notes

Cytotoxic C-Benzylated Dihydrochalcones from Uvaria acuminata

Momoyo Ichimaru, Noriyoshi Nakatani, Tomoko Takahashi, Yumi Nishiyama, Masataka Moriyasu, Atsushi Kato, Simon G. Mathenge, Francis D. Juma, Joseph N. Nganga

Author information

Momoyo Ichimaru
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
Noriyoshi Nakatani
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
Tomoko Takahashi
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
Yumi Nishiyama
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
Masataka Moriyasu
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
Atsushi Kato
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University
Simon G. Mathenge
Department of Botany, University of Nairobi
Francis D. Juma
Department of Medicine, University of Nairobi
Joseph N. Nganga
Department of Medicine, University of Nairobi

Keywords: Uvaria acuminata, C-benzylated dihydrochalcone, cytotoxicity against HL-60 cell

JOURNAL FREE ACCESS

2004 Volume 52 Issue 1 Pages 138-141

DOI https://doi.org/10.1248/cpb.52.138

Details

Abstract

Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7). The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells.

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