Synthesis of Hexahydropyridazine-3-phosphonic Acid

Mamoru Kaname; Kazuo Yoshinaga; Yasushi Arakawa; Shigeyuki Yoshifuji

doi:10.1248/cpb.52.160

Notes

Synthesis of Hexahydropyridazine-3-phosphonic Acid

Mamoru Kaname, Kazuo Yoshinaga, Yasushi Arakawa, Shigeyuki Yoshifuji

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Keywords: hexahydropyridazine-3-phosphonic acid, phosphonylation, one-pot reaction, piperidazine-3-phosphonic acid, α-hydrazinophosphonic acid, hetero-Diels–Alder reaction

JOURNAL FREE ACCESS

2004 Volume 52 Issue 1 Pages 160-162

DOI https://doi.org/10.1248/cpb.52.160

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Abstract

The synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels–Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.

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