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Chemical and Pharmaceutical Bulletin
Vol. 52 (2004) No. 11 P 1269-1272

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http://doi.org/10.1248/cpb.52.1269

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Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.

Copyright © 2004 The Pharmaceutical Society of Japan

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