Novel and Simple Preparation Method of Matrix-Type Composite Particles for Controlled Drug Release by Mechanical Action

Abstract

Matrix-type composite particle for controlled drug release can readily be prepared through a totally dry process by simple anaerobic mechanical vibration of mechanoradical-containing ethylcellulose (EC) with theophylline powder due to occurrence of collision-induced radical–radical coupling reaction to form interparticle matrices, as well as the formation of interparticle network when solid-state vinyl monomer was further added.