Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Nigellamines A3, A4, A5, and C, New Dolabellane-Type Diterpene Alkaloids, with Lipid Metabolism-Promoting Activities from the Egyptian Medicinal Food Black Cumin
Toshio MorikawaFengming XuKiyofumi NinomiyaHisashi MatsudaMasayuki Yoshikawa
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2004 Volume 52 Issue 4 Pages 494-497


New dolabellane-type diterpene alkaloids, nigellamines A3, A4, A5, and C, were isolated from the methanolic extract of an Egyptian medicinal food, black cumin (the seeds of Nigella sativa). Their absolute configurations were determined on the basis of chemical and physicochemical evidence. Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A5 was equivalent to that of the hypolipidemic agent, clofibrate.

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© 2004 The Pharmaceutical Society of Japan
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