Solid-Phase Tandem Radical Addition-Cyclization Reaction: Triethylborane-Induced Reaction of Oxime Ethers Anchored to Polymer Support

Abstract

Tandem radical addition-cyclization of oxime ethers anchored to polymer support was studied. The reaction of oxime ethers with stannyl radical proceeded effectively by the use of triethylborane as a radical initiator. The alkyl radical addition-cyclization reactions of oxime ether connected with α,β-unsaturated carbonyl group proceeded under iodine atom-transfer reaction conditions to give the functionalized azacycles via two carbon–carbon bonds-forming process.