3,5-Nonadiyne Isolated from the Rhizome of Cachrys ferulacea Inhibits Endogenous Nitric Oxide Release by Rat Peritoneal Macrophages

Dejan D. Đoković; Vanja M. Bulatović; Biljana Đ. Božić; Milena V. Kataranovski; Tomislav M. Zrakić; Nada N. Kovačević

doi:10.1248/cpb.52.853

Notes

3,5-Nonadiyne Isolated from the Rhizome of Cachrys ferulacea Inhibits Endogenous Nitric Oxide Release by Rat Peritoneal Macrophages

Dejan D. Đoković, Vanja M. Bulatović, Biljana Đ. Božić, Milena V. Kataranovski, Tomislav M. Zrakić, Nada N. Kovačević

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Keywords: 3,5-nonadiyne, Cachrys ferulacea, Prangos ferulacea, endogenous nitric oxide, inhibition

JOURNAL FREE ACCESS

2004 Volume 52 Issue 7 Pages 853-854

DOI https://doi.org/10.1248/cpb.52.853

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Abstract

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC₅₀=6.7±0.8 μM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.

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