New Cytotoxic Cardenolide Glycoside from the Seeds of Cerbera manghas

Abstract

A new cytotoxic cardenolide glycoside, 3β-O-(2′-O-acetyl-α-L-thevetosyl)-14β-hydroxy-7-en-5β-card-20(22)-enolide, (7,8-dehydrocerberin), together with five known cardenolides, 17β-neriifolin, deacetyltanghinin, tanghinin, cerberin and 2′-O-acetyl-cerleaside A were isolated from the seeds of Cerbera manghas L. Their structures were elucidated by 1D- and 2D-NMR techniques as well as UV, IR and mass spectral data. 7,8-Dehydrocerberin, deacetyltanghinin and tanghinin exhibited cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cells lung cancer (NCI-H187).