Sesquiterpene Aminoquinones, from a Marine Sponge, Induce Erythroid Differentiation in Human Chronic Myelogenous Leukemia, K562 Cells

Shunji Aoki; Dexin Kong; Kouhei Matsui; Rachmaniar Rachmat; Motomasa Kobayashi

doi:10.1248/cpb.52.935

Regular Articles

Sesquiterpene Aminoquinones, from a Marine Sponge, Induce Erythroid Differentiation in Human Chronic Myelogenous Leukemia, K562 Cells

Shunji Aoki, Dexin Kong, Kouhei Matsui, Rachmaniar Rachmat, Motomasa Kobayashi

著者情報

キーワード: 5-epi-smenospongorine, erythroid differentiation, structure–activity relationship, K562 cells, marine sponge

ジャーナルフリー

2004 年 52 巻 8 号 p. 935-937

DOI https://doi.org/10.1248/cpb.52.935

詳細

抄録

A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure–activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.

責任著者(Corresponding author)

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