Synthesis of Optically Active Methyl 7β-Hydroxykaurenoate with Potent Neuroprotective Activity

Masahiro Toyota; Kiminori Matsuura; Masahiro Yokota; Manami Kimura; Masahiro Yonaga; Hachiro Sugimoto; Masataka Ihara

doi:10.1248/cpb.52.1153

Communications to the Editor

Synthesis of Optically Active Methyl 7β-Hydroxykaurenoate with Potent Neuroprotective Activity

Masahiro Toyota, Kiminori Matsuura, Masahiro Yokota, Manami Kimura, Masahiro Yonaga, Hachiro Sugimoto, Masataka Ihara

著者情報

キーワード: kaurene diterpenoid, neuroprotective activity, chiral synthesis, radical cyclization

ジャーナルフリー

2004 年 52 巻 9 号 p. 1153-1154

DOI https://doi.org/10.1248/cpb.52.1153

詳細

抄録

(−)-Methyl 7β-hydroxykaurenoate (3) and its 4-demethyl acetate (−)-4 were both synthesized via methods that contained radical cyclization and intramolecular Diels-Alder reactions as key steps. Both compounds displayed potent neuroprotective activity against N-methyl-D-aspartate toxicity in cultured cortical neurons.

責任著者(Corresponding author)

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