A Facile Synthesis of Novel Chiral Phosphonoacetates Bearing a Stereogenic Phosphorus Atom

Shigeki Sano; Eiko Kujime; Yuka Takemoto; Motoo Shiro; Yoshimitsu Nagao

doi:10.1248/cpb.53.131

Notes

A Facile Synthesis of Novel Chiral Phosphonoacetates Bearing a Stereogenic Phosphorus Atom

Shigeki Sano, Eiko Kujime, Yuka Takemoto, Motoo Shiro, Yoshimitsu Nagao

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Keywords: chiral phosphonoacetate, stereogenic phosphorus atom, kinetic resolution, enzymatic hydrolysis, porcine liver esterase, Horner–Wadsworth–Emmons reagent

JOURNAL FREE ACCESS

2005 Volume 53 Issue 1 Pages 131-134

DOI https://doi.org/10.1248/cpb.53.131

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Abstract

Novel chiral phosphonoacetates bearing a stereogenic phosphorus atom were successfully synthesized by enzyme-catalyzed kinetic resolution of racemic phosphonoacetates.

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