Antimycobacterial and Antiplasmodial Unsaturated Carboxylic Acid from the Twigs of Scleropyrum wallichianum

Apichart Suksamrarn; Matee Buaprom; Saifon Udtip; Nuchnipa Nuntawong; Rachada Haritakun; Somdej Kanokmedhakul

doi:10.1248/cpb.53.1327

Notes

Antimycobacterial and Antiplasmodial Unsaturated Carboxylic Acid from the Twigs of Scleropyrum wallichianum

Apichart Suksamrarn, Matee Buaprom, Saifon Udtip, Nuchnipa Nuntawong, Rachada Haritakun, Somdej Kanokmedhakul

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Keywords: Scleropyrum wallichianum, scleropyric acid, β-sitosteryl-3-O-scleropyrate, stigmasteryl-3-O-scleropyrate, antimycobacterial activity, antiplasmodial activity

JOURNAL FREE ACCESS

2005 Volume 53 Issue 10 Pages 1327-1329

DOI https://doi.org/10.1248/cpb.53.1327

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Abstract

From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 μg/ml and showed antiplasmodial activity with an IC₅₀ value of 7.2 μg/ml. Compounds 2 and 3 were inactive in both assays.

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