Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Notes
Synthesis of New Dihydropyrazines with DNA Strand-Breakage Activity
Hiroshi MaruokaNobuhiro KashigeFumio MiakeTadatoshi Yamaguchi
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2005 Volume 53 Issue 10 Pages 1359-1361

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Abstract

Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis-(and trans-)1,2-diaminocyclohexane, caused [4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1—6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers.

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© 2005 The Pharmaceutical Society of Japan
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