Cytotoxic Limonoids from Brazilian Melia azedarach

Honglei Zhou; Atsuko Hamazaki; Jose Domingos Fontana; Hironobu Takahashi; Carolina Bueno Wandscheer; Yoshiyasu Fukuyama

doi:10.1248/cpb.53.1362

Notes

Cytotoxic Limonoids from Brazilian Melia azedarach

Honglei Zhou, Atsuko Hamazaki, Jose Domingos Fontana, Hironobu Takahashi, Carolina Bueno Wandscheer, Yoshiyasu Fukuyama

著者情報

キーワード: tetranortriterpenoid, limonoid, Melia azedarach, cytotoxicity

ジャーナルフリー

2005 年 53 巻 10 号 p. 1362-1365

DOI https://doi.org/10.1248/cpb.53.1362

詳細

抄録

Three new C-seco limonoids (1—3) and one new tetracyclic limonoid (4) were isolated from a methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Brazil, and their structures were elucidated by spectroscopic data analysis and comparison of spectral data with those of the previously known compounds. Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity.

責任著者(Corresponding author)

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