Practical Synthesis of Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]

Hideyuki Tsutsui; Takumi Abe; Seiichi Nakamura; Masahiro Anada; Shunichi Hashimoto

doi:10.1248/cpb.53.1366

Notes

Practical Synthesis of Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]

Hideyuki Tsutsui, Takumi Abe, Seiichi Nakamura, Masahiro Anada, Shunichi Hashimoto

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Keywords: tert-leucine, N-phthaloylation, dirhodium(II) carboxylate, chiral catalyst

JOURNAL FREE ACCESS

2005 Volume 53 Issue 10 Pages 1366-1368

DOI https://doi.org/10.1248/cpb.53.1366

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Abstract

An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh₂(S-PTTL)₄, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.

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