Superoxide Anion-Scavenging Effect of 2-Amino-1,3-selenazoles

Abstract

We investigated the superoxide anion scavenging effects of thirteen 2-amino-1,3-selenazoles using a highly sensitive quantitative chemiluminescence method. At 166 μM, the 2-amino-1,3-selenazoles scavenged in the range of 14.3 to 96.7% of O₂⁻. 2-Piperidino-1,3-selenazole and 4-phenyl-2-piperidino-1,3-selenazole exhibited the strongest superoxide anion-scavenging activity among the 2-amino-1,3-selenazoles. The 50% inhibitory concentrations (IC₅₀) of 2-piperidino-1,3-selenazole and 4-phenyl-2-piperidino-1,3-selenazole were determined to be 4.03 μM and 92.6 μM, respectively. Thus, these compounds acted in vitro as effective O₂⁻ scavengers.