Highly Regioselective Palladium-Catalyzed Annulation Reactions of Heteroatom-Substituted Allenes for Synthesis of Condensed Heterocycles

Kiyofumi Inamoto; Akio Yamamoto; Kazutoshi Ohsawa; Kou Hiroya; Takao Sakamoto

doi:10.1248/cpb.53.1502

Notes

Highly Regioselective Palladium-Catalyzed Annulation Reactions of Heteroatom-Substituted Allenes for Synthesis of Condensed Heterocycles

Kiyofumi Inamoto, Akio Yamamoto, Kazutoshi Ohsawa, Kou Hiroya, Takao Sakamoto

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Keywords: palladium, annulation, allene, heterocycle, alkyl metal reagent

JOURNAL FREE ACCESS

2005 Volume 53 Issue 11 Pages 1502-1507

DOI https://doi.org/10.1248/cpb.53.1502

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Abstract

We have developed a highly regioselective synthesis of heterocycles via palladium-catalyzed annulation reaction of heteroatom-substituted allenes. Various aryl halides were reacted and one regioisomer was observed exclusively in all reactions. In addition, subsequent functionalizations of annulated products were carried out using alkyl metal reagents, and the introduction of alkyl moieties was accomplished.

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