Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Communications to the Editor
Highly Efficient Production of Nootkatone, the Grapefruit Aroma from Valencene, by Biotransformation
Mai FurusawaToshihiro HashimotoYoshiaki NomaYoshinori Asakawa
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2005 Volume 53 Issue 11 Pages 1513-1514

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Abstract

Nootkatone (2), the most important and expensive aromatic of grapefruit, decreases the somatic fat ratio, and thus its demand is increasing in the cosmetic and fiber sectors. A sesquiterpene hydrocarbon, (+)-valencene (1), which is cheaply obtained from Valencia orange, was biotransformed by the green algae Chlorella species and fungi such as Mucor species, Botryosphaeria dothidea, and Botryodiplodia theobromae to afford nootkatone (2) in high yield.

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© 2005 The Pharmaceutical Society of Japan
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