A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens

Tsutomu Nakanishi; Yuka Inatomi; Hiroko Murata; Kaori Shigeta; Naoki Iida; Akira Inada; Jin Murata; Miguel Angel Perez Farrera; Munekazu Iinuma; Toshiyuki Tanaka; Shogo Tajima; Naoto Oku

doi:10.1248/cpb.53.229

Notes

A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens

Tsutomu Nakanishi, Yuka Inatomi, Hiroko Murata, Kaori Shigeta, Naoki Iida, Akira Inada, Jin Murata, Miguel Angel Perez Farrera, Munekazu Iinuma, Toshiyuki Tanaka, Shogo Tajima, Naoto Oku

著者情報

キーワード: Bursera graveolens, 4α-aryltetralin-type lignan, burseranin, picropolygamain, cytotoxic activity, Burseraceae

ジャーナルフリー

2005 年 53 巻 2 号 p. 229-231

DOI https://doi.org/10.1248/cpb.53.229

詳細

抄録

A new 4α-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.

責任著者(Corresponding author)

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