Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Regular Articles
Cytotoxic Diterpenoids from Vietnamese Medicinal Plant Croton tonkinensis GAGNEP.
Phan Minh GiangPhan Tong SonYumi HamadaHideaki Otsuka
著者情報
ジャーナル フリー

2005 年 53 巻 3 号 p. 296-300

詳細
抄録

Six new ent-kaurane-type diterpenoids were isolated from the leaves of the endemic Vietnamese medicinal plant Croton tonkinensis GAGNEP. (Euphorbiaceae) together with three known ent-11α-acetoxy-7β,14α-dihydroxykaur-16-en-15-one (1), ent-kaur-16-en-15-one 18-oic acid (5) and ent-18-hydroxykaur-16-ene (7). Their structures were determined by spectroscopic analyses to be ent-7β-acetoxy-11α-hydroxykaur-16-en-15-one (2), ent-18-acetoxy-11α-hydroxykaur-16-en-15-one (3), ent-11α-acetoxykaur-16-en-18-oic acid (4), ent-15α,18-dihydroxykaur-16-ene (6), ent-11α,18-diacetoxy-7β-hydroxykaur-16-en-15-one (8), and ent-(16S)-1α,14α-diacetoxy-7β-hydroxy-17-methoxykauran-15-one (14). ent-Kaurane-type diterpenoids from Croton tonkinensis 2—4, 6, and 9—13, were tested for toxicity in the brine shrimp lethality assay. Compounds 9, 10, and 12 demonstrated significant activity, compounds 2, 3, 6, and 11 showed weak activity, and compounds 4 and 13 were inactive.

著者関連情報
© 2005 The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top