Constituents of Zingiber aromaticum and Their CYP3A4 and CYP2D6 Inhibitory Activity

Subehan; Tepy Usia; Shigetoshi Kadota; Yasuhiro Tezuka

doi:10.1248/cpb.53.333

Notes

Constituents of Zingiber aromaticum and Their CYP3A4 and CYP2D6 Inhibitory Activity

Subehan, Tepy Usia, Shigetoshi Kadota, Yasuhiro Tezuka

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Keywords: Zingiber aromaticum, Indonesian medicinal plant, cytochrome P450 3A4 (CYP3A4), cytochrome P450 2D6 (CYP2D6), human liver microsome, drug–herb interaction

JOURNAL FREE ACCESS

2005 Volume 53 Issue 3 Pages 333-335

DOI https://doi.org/10.1248/cpb.53.333

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Abstract

A new sesquiterpene 2,9-humuladien-6-ol-8-one (1) was isolated from methanol extract of Zingiber aromaticum, along with 15 known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibitory activity on the metabolism mediated by cytochrome P450 3A4 (CYP3A4) and CYP2D6.

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