Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Notes
An Antibacterial Biphenyl Derivative from Garcinia bancana MIQ.
Vatcharin RukachaisirikulWanpen NaklueYaowapa SukpondmaSouwalak Phongpaichit
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2005 年 53 巻 3 号 p. 342-343

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From the methanol extract of the twigs and leaves of Garcinia bancana MIQ., one new biphenyl derivative (1), was isolated and characterized along with nine known compounds; garcinol, isogarcinol, (−)-mellein, 8-hydroxy-6-methoxy-3-n-pentylisocoumarin, blumenol C O-β-D-glucoside, quercetin 3-O-α-L-rhamnoside, kaemferol 3-O-α-L-rhamnoside, lupeol and stigmasterol. Their structures were determined by analysis of 1D and 2D NMR data and comparison of spectral data and physical data with those previously reported. The antibacterial activity against methicillin-resistant Staphylococcus aureus was evaluated. Garcinol showed the lowest minimum inhibition concentration (MIC) at 16 μg/ml while compound 1 exhibited weaker activity with MIC value of 64 μg/ml.
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© 2005 The Pharmaceutical Society of Japan
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