Three New Cholinesterase-Inhibiting cis-Clerodane Diterpenoids from Otostegia limbata

Viqar Uddin Ahmad; Afsar Khan; Umar Farooq; Farzana Kousar; Saleha Suleman Khan; Sarfraz Ahmad Nawaz; Muhammad Athar Abbasi; Muhammad Iqbal Choudhary

doi:10.1248/cpb.53.378

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Three New Cholinesterase-Inhibiting cis-Clerodane Diterpenoids from Otostegia limbata

Viqar Uddin Ahmad, Afsar Khan, Umar Farooq, Farzana Kousar, Saleha Suleman Khan, Sarfraz Ahmad Nawaz, Muhammad Athar Abbasi, Muhammad Iqbal Choudhary

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Keywords: Lamiaceae, Otostegia limbata, clerodane diterpenoid, cholinesterase inhibitory assay

JOURNAL FREE ACCESS

2005 Volume 53 Issue 4 Pages 378-381

DOI https://doi.org/10.1248/cpb.53.378

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Abstract

Three new tricyclic cis-clerodane type diterpenoids trivially named as limbatolide A (1), limbatolide B (2) and limbatolide C (3) have been isolated from the roots of Otostegia limbata along with two known compounds; oleanic acid and β-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D) NMR techniques. Compounds 1—3 displayed inhibitory potential in a concentration-dependent manner against acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) enzymes, respectively.

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