2′-Amino-α-chloroacetophenone as a Valuable Tool for the Synthesis of Conveniently-Substituted α,β-Epoxychalcone Derivatives

Abstract

The synthesis of conveniently substituted 2′-amino-α,β-epoxychalcones is described. They were obtained through Darzens condensation of 2′-amino-3′,5′-dimethoxy-α-chloroacetophenone with benzaldehydes. The latter can undergo different cyclization possibilities and afford a variety of flavonoid analogs with biological potential.