In Vitro Alpha-glucosidase Inhibitory Effect of Zn(II) Complex with 6-Methyl-2-picolinmethylamide

Eriko Ueda; Yutaka Yoshikawa; Hiromu Sakurai; Yoshitane Kojima; Naemi M. Kajiwara

doi:10.1248/cpb.53.451

Communications to the Editor

In Vitro Alpha-glucosidase Inhibitory Effect of Zn(II) Complex with 6-Methyl-2-picolinmethylamide

Eriko Ueda, Yutaka Yoshikawa, Hiromu Sakurai, Yoshitane Kojima, Naemi M. Kajiwara

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Keywords: Zn(II) complex, alpha-glucosidase, 6-methyl-2-picolinmethylamide

JOURNAL FREE ACCESS

2005 Volume 53 Issue 4 Pages 451-452

DOI https://doi.org/10.1248/cpb.53.451

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Abstract

We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A^y mice. The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.

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