Synthesis of Poison-Frog Alkaloids 237D, 207A, and Two Congeners of 235B′ for Evaluation to Inhibitory Effect of Nicotinic Acetylcholine Receptors

Naoki Toyooka; Masashi Kawasaki; Hideo Nemoto

doi:10.1248/cpb.53.555

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Synthesis of Poison-Frog Alkaloids 237D, 207A, and Two Congeners of 235B′ for Evaluation to Inhibitory Effect of Nicotinic Acetylcholine Receptors

Naoki Toyooka, Masashi Kawasaki, Hideo Nemoto

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Keywords: poison-frog alkaloid, 237D, 207A, 235B′, 5,8-disubstituted indolizidine

JOURNAL FREE ACCESS

2005 Volume 53 Issue 5 Pages 555-560

DOI https://doi.org/10.1248/cpb.53.555

[Correction] Chem. Pharm. Bull. Vol.54 (2006) No.12 pp.1745-1747

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Abstract

Enantioselective synthesis of the poison-frog alkaloids 237D, 207A, and two congeners of 235B′ has been achieved. The absolute stereochemistry of 237D was determined to be 5S, 8S, 9R by the present synthesis.

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