Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Communications to the Editor
Biooxidation of (+)-Catechin and (−)-Epicatechin into 3,4-Dihydroxyflavan Derivatives by the Endophytic Fungus Diaporthe sp. Isolated from a Tea Plant
Hirotaka ShibuyaAndria AgustaKazuyoshi OhashiShoji MaeharaPartomuan Simanjuntak
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Volume 53 (2005) Issue 7 Pages 866-867

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Abstract

The microbial transformation of (+)-catechin (1) and (−)-epicatechin (2) by endophytic fungi isolated from a tea plant was investigated. It was found that the endophytic filamentous fungus Diaporthe sp. transformed them (1, 2) into the 3,4-cis-dihydroxyflavan derivatives, (+)-(2R,3S,4S)-3,4,5,7,3′,4′-hexahydroxyflavan (3) and (−)-(2R,3R,4R)-3,4,5,7,3′,4′-hexahydroxyflavan (7), respectively, whereas (−)-catechin (ent-1) and (+)-epicatechin (ent-2) with a 2S-phenyl group resisted the biooxidation.

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© 2005 The Pharmaceutical Society of Japan
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