Concise Synthesis of dl-Febrifugine

Yasuo Takeuchi; Miyo Oshige; Kumiko Azuma; Hitoshi Abe; Takashi Harayama

doi:10.1248/cpb.53.868

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

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Concise Synthesis of dl-Febrifugine

Yasuo Takeuchi, Miyo Oshige, Kumiko Azuma, Hitoshi Abe, Takashi Harayama

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Keywords: total synthesis, stereoselective Michael reaction, Wittig reaction, febrifugine, antimalarial activity

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Volume 53 (2005) Issue 7 Pages 868-869

DOI https://doi.org/10.1248/cpb.53.868

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Abstract

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

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