Microbial Transformation of Mestranol by Cunninghamella elegans

Muhammad Iqbal Choudhary; Syed Ghulam Musharraf; Zafar Ali Siddiqui; Naik Tameen Khan; Rahat Azhar Ali; Atta-ur-Rahman

doi:10.1248/cpb.53.1011

Notes

Microbial Transformation of Mestranol by Cunninghamella elegans

Muhammad Iqbal Choudhary, Syed Ghulam Musharraf, Zafar Ali Siddiqui, Naik Tameen Khan, Rahat Azhar Ali, Atta-ur-Rahman

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Keywords: mestranol, 17β-methoxymestranol, microbial transformation, Cunninghamella elegans

JOURNAL FREE ACCESS

2005 Volume 53 Issue 8 Pages 1011-1013

DOI https://doi.org/10.1248/cpb.53.1011

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Abstract

The microbial transformation of an oral contraceptive, mestranol (1) by Cunninghamella elegans yielded two hydroxylated metabolites, 6β-hydroxymestranol (2) and 6β,12β-dihydroxymestranol (3). Metabolite 3 was found to be a new compound. These metabolites were structurally characterized on the basis of spectroscopic techniques.

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