2005 Volume 53 Issue 8 Pages 1034-1036
From the antibacterial fraction of the roots of Garcinia kola, 3″,4′,4′′′,5,5″,7,7″-heptahydroxy-3,8″-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128 μg/ml, respectively.