Evaluation of Strychnos pseudoquina S<small>T</small>. H<small>IL</small>. Leaves Extract on Gastrointestinal Activity in Mice

Marcelo Aparecido da Silva; Bruna Paola Murino Rafacho; Clelia Akiko Hiruma-Lima; Lúcia Regina Machado da Rocha; Lourdes Campaner dos Santos; Miriam Sannomiya; Alba Regina Monteiro Souza-Brito; Wagner Vilegas

doi:10.1248/cpb.53.881

Regular Articles

Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice

Marcelo Aparecido da Silva, Bruna Paola Murino Rafacho, Clelia Akiko Hiruma-Lima, Lúcia Regina Machado da Rocha, Lourdes Campaner dos Santos, Miriam Sannomiya, Alba Regina Monteiro Souza-Brito, Wagner Vilegas

Author information

Keywords: Strychnos pseudoquina, antiulcer activity, toxic activity, alkaloid

JOURNAL FREE ACCESS

2005 Volume 53 Issue 8 Pages 881-885

DOI https://doi.org/10.1248/cpb.53.881

Details

Abstract

Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.

Corresponding author

Register with J-STAGE for free!