Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Release from or through a Wax Matrix System. VI. Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet
Yorinobu YonezawaSumio IshidaHisakazu Sunada
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Volume 53 (2005) Issue 8 Pages 915-918

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Abstract

Analysis of the entire release process of the wax matrix tablet was examined. Wax matrix tablet was prepared from a physical mixture of drug and wax powder to obtain basic or clear release properties. The release process began to deviate from Higuchi equation when the released amount reached at around the half of the initial drug amount. Simulated release amount increase infinitely when the Higuchi equation was applied. Then, the Higuchi equation was modified to estimate the release process of the wax matrix tablet. The modified Higuchi equation was named as the H-my equation. Release process was well treated by the H-my equation. Release process simulated by the H-my equation fitted well with the measured entire release process. Also, release properties from and through wax matrix well coincident each other. Furthermore, it is possible to predict an optional release process when the amount of matrix and composition of matrix system were defined.

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© 2005 The Pharmaceutical Society of Japan
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