Two New Meroterpenoids, Penisimplicin A and B, Isolated from Penicillium simplicissimum

Shin-ichirou Komai; Tomoo Hosoe; Takeshi Itabashi; Koohei Nozawa; Kaoru Okada; Galba Maria de Campos Takaki; Takashi Yaguchi; Kayoko Takizawa; Kazutaka Fukushima; Ken-ichi Kawai

doi:10.1248/cpb.53.1114

Regular Articles

Two New Meroterpenoids, Penisimplicin A and B, Isolated from Penicillium simplicissimum

Shin-ichirou Komai, Tomoo Hosoe, Takeshi Itabashi, Koohei Nozawa, Kaoru Okada, Galba Maria de Campos Takaki, Takashi Yaguchi, Kayoko Takizawa, Kazutaka Fukushima, Ken-ichi Kawai

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Keywords: Penicillium simplicissimum, meroterpenoid, penisimplicin A, penisimplicin B, andrastin A

JOURNAL FREE ACCESS

2005 Volume 53 Issue 9 Pages 1114-1117

DOI https://doi.org/10.1248/cpb.53.1114

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Abstract

In the course of our rsearch for new antifungal agents, two new meroterpenoids, penisimplicin A (1) and B (2), were isolated from Penicillium simplicissimum. The absolute structures of 1 and 2 were established by spectroscopic and chemical investigation. Penisimplicin A (1) and B (2) are rare examples of D-ring seco-meroterpenoids. Since compounds 1 and 2 showed no antifungal activities, the isolation of the compounds with antifungal activity will be attempted.

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