New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum

Jun Mori; Makoto Iwashima; Hiroko Wakasugi; Haruo Saito; Takayuki Matsunaga; Masaru Ogasawara; Satoshi Takahashi; Hideyo Suzuki; Toshimitsu Hayashi

doi:10.1248/cpb.53.1159

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New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum

Jun Mori, Makoto Iwashima, Hiroko Wakasugi, Haruo Saito, Takayuki Matsunaga, Masaru Ogasawara, Satoshi Takahashi, Hideyo Suzuki, Toshimitsu Hayashi

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Keywords: plastoquinone, antioxidative activity, lipid peroxidation, radical scavenger, cytotoxic activity, Sargassum micracanthum

JOURNAL FREE ACCESS

2005 Volume 53 Issue 9 Pages 1159-1163

DOI https://doi.org/10.1248/cpb.53.1159

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Abstract

Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.

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