Chymotrypsin Inhibitory Triterpenoids from Silybum marianum

Ejaz Ahmed; Abdul Malik; Sadia Ferheen; Nighat Afza; Azhar-ul-H<aq; Muhammad Arif Lodhi; Muhammad Iqbal Choudhary

doi:10.1248/cpb.54.103

Notes

Chymotrypsin Inhibitory Triterpenoids from Silybum marianum

Ejaz Ahmed, Abdul Malik, Sadia Ferheen, Nighat Afza, Azhar-ul-H, Muhammad Arif Lodhi, Muhammad Iqbal Choudhary

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Keywords: Silybum marianum, marianine, marianoside A, marianoside B, chymotrypsin inhibition

JOURNAL FREE ACCESS

2006 Volume 54 Issue 1 Pages 103-106

DOI https://doi.org/10.1248/cpb.54.103

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Abstract

Marianine, the new lanostane triterpene (1) and marianosides A (2) and B (3) have been isolated from the whole plant of Silybum marianum. Their structures were elucidated on the basis of extensive analysis of their one dimensional and two dimensional nuclear magnetic resonance (1D, 2D-NMR) spectral data. All inhibited chymotrypsin in a concentration-dependent manner.

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