Iridoids and Sesquiterpenoids with NGF-Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei

Yuanqiang Guo; Jing Xu; Yushan Li; Ryuichi Watanabe; Yasukatsu Oshima; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1248/cpb.54.123

Notes

Iridoids and Sesquiterpenoids with NGF-Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei

Yuanqiang Guo, Jing Xu, Yushan Li, Ryuichi Watanabe, Yasukatsu Oshima, Tohru Yamakuni, Yasushi Ohizumi

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Keywords: Valeriana fauriei, iridoid glycoside, sesquiterpenoid, nerve growth factor (NGF)-potentiating activity

JOURNAL FREE ACCESS

2006 Volume 54 Issue 1 Pages 123-125

DOI https://doi.org/10.1248/cpb.54.123

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Abstract

A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

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