Three New Lignans, Longipedunins A—C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease

Quan-Zhong Sun; Dao-Feng Chen; Pei-Lan Ding; Chao-Mei Ma; Hiroko Kakuda; Norio Nakamura; Masao Hattori

doi:10.1248/cpb.54.129

Notes

Three New Lignans, Longipedunins A—C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease

Quan-Zhong Sun, Dao-Feng Chen, Pei-Lan Ding, Chao-Mei Ma, Hiroko Kakuda, Norio Nakamura, Masao Hattori

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Keywords: longipedunin, Kadsura longipedunculata, HIV-1 protease, lignan, X-ray crystal structure

JOURNAL FREE ACCESS

2006 Volume 54 Issue 1 Pages 129-132

DOI https://doi.org/10.1248/cpb.54.129

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Abstract

Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC₅₀ values of 50 and 20 μM, respectively.

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