Triterpenoid Saponins from Lysimachia davurica

Abstract

Three new saponins were isolated from the whole plants of Lysimachia davurica. On the basis of 1D and 2D NMR (¹H–¹HCOSY, HMBC, HMQC, and TOCSY) techniques, MS, and hydrolysis, their structures were found to be 3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl-13,28-epoxy-3β-hydroxy-16-oleanaone (1), 3-O-β-D-glucopyranosyloxyuronic acid-(1→2)-β-D-xylopyranosyl-cyclamiretin A (2), and 3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-cyclamiretin A (3), respectively. Compounds 2 and 3 showed significant cytotoxicities against human A-2780 cells.